Biomaterial scaffolds show advanced mechanical properties and a good degradation profile, as well as the feasibility of controlled release of growth and differentiation factors or immobilizing them on the material surface. Recently, nano/micro-assisted regenerative medicine becomes a promising application of TE (tissue engineering) for the reconstruction of bone defects. We herein review the hierarchical structure of bone, and the potential application of nano/microtechnologies to guide the design of novel biomaterial structures for bone repair and regeneration.
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