Lieber’s team used photolithography to develop their ‘neuron-like electronics’ (NeuE) with an impressive size scale of only ~0.9 μm in total thickness, comparable to a myelinated axon (Fig. 1a). Utilizing their previously published methods for insertion6, they were able to successfully implant ~80% of their animals across several brain structures. Full three-dimensional mapping of implanted NeuE devices displayed the intimate integration between the NeuE devices and native neurons (Fig. 1b), complete with triangulated positioning of the presumptive neuron believed responsible to the units recorded across electrode contacts.
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