Scientists at Scripps Research have unveiled a new tissue-clearing method for rendering large biological samples transparent. The method makes it easier than ever for scientists to visualize and study healthy and disease-related biological processes occurring across multiple organ systems.
Described in a paper in Nature Methods on March 28, 2022, and dubbed HYBRiD, the new method combines elements of the two main prior approaches to tissue-clearing technology, and should be more practical and scalable than either for large-sample applications.
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