News, Basis of Daily Rhythms Revealed in Simplest Biological Clock
In a new study, Japanese structural biologists from the National Institutes of Natural Sciences in Okazaki, Japan, and their collaborators from SOKENDAI, Nagoya, and Osaka Universities, tackled the complex workings of the simplest of all biological clock mechanisms in the cyanobacterium (Synechococcus elongatus) and provided insights on its regulation.
The study was published in an article in the journal Science Advances (“Elucidation of master allostery essential for circadian clock oscillation in cyanobacteria”).
The rhythmic orderliness of complex biological phenomena in space and time depends on diurnal molecular clock systems. Oscillations in a variety of cellular activities are generated by clock mechanisms through allosteric cooperation, where protein components are chemically modified at multiple locations in a programmed manner to alter their binding characteristics with other clock proteins.
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