New biological tools provide new techniques to probe fundamental biological processes. Here we describe the burgeoning field of proteolysis-targeting chimeras (PROTACs), which are capable of modulating protein concentrations at a post-translational level by co-opting the ubiquitin-proteasome system. We describe the PROTAC technology and its application to drug […]
Bioengineered pathogens for drug delivery.
Abstract: Synthetic carriers such as polymer and lipid particles often struggle to meet clinical expectations. Natural particulates — that range from pathogens to mammalian cells — are therefore worth examining in more depth, as they are highly optimized for their specific functions in vivo and possess features that are often desired […]
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