The paper discusses the significance of the newly designed voltage dependent calcium channel blockers. These channels facilitate the conversion of membrane electrical signals into Ca 2+ influx. This process helps in scenarios ranging from muscle contraction to synaptic transmission. These channel blockers are very important in aiding those who suffer from hypertension, strokes, neuropathic pain, Alzheimer’s disease, and many more conditions. These channel blockers are inspired by the discovery of a G-protein called Rem which inhibits Cav1 and Cav2 channels. Moreover, it was proven that differential tuning of the Cav1 and Cav2 channels can be done to optimize its performance in a variety of conditions. Data was collected to show that the positioning of the membrane-targeting domain affects the effectiveness of the channel blockers. An associated protein called ChIMP can also be used to develop ion channel blockers.
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